Global Translational Bioinformatics Lead

General Information

Job Advert Title: Global Translational Bioinformatics Lead

Location: Nihonbashi,Tokyo

Division: Early Development

Employment Class: Permanent

Description

【募集の背景 / Purpose & Scope】 Responsible for providing bioinformatics expertise to drug target selection, translational research, patient selection strategy and clinical biomarker analysis for multiple drug discovery and development programs. Develop bioinformatics analysis plans, perform hands-on analyses, and generate reports on internal and external data sets related to Astellas/partner discovery and development programs. Responsibilities also include developing new bioinformatics capabilities to support new modalities and therapeutic focus areas.
【職務の内容 / Essential Job Responsibilities】 （雇入れ直後） •Leads bioinformatics strategy and develop analysis plans to address asset team’s clinical development questions •Utilizes state of the art bioinformatics methods, internal and external data to address translational questions related to indication selection, patient segmentation, and biomarker identification •Conducts bioinformatics analysis of clinical trial omics data to support POM and patient selection •Supports data ingestion and conducts analysis using translational and biomarker data management platforms •Selects the appropriate data sets and analytical approaches for drug target identification and validation to support drug research •Develops new analysis tools and databases to meet the current and future portfolio needs •Identifies and evaluates external resources (CRO/academic collaborator) to complement internal capabilities
（変更の範囲） 会社内での全ての業務
【就業環境に関する要件 / Specific Physical or Environmental Requirements】 •This position is a hybrid role and can be based in US, Japan, UK and EU •(OR) At Astellas we recognize the importance of work/life balance, and we are proud to offer a hybrid working solution allowing time to connect with colleagues at the office with the flexibility to also work from home. We believe this will optimize the most productive work environment for all employees to succeed and deliver. Hybrid work from certain locations may be permitted in accordance with Astellas’ Responsible Flexibility Guidelines.
【応募要件 / Qualifications】 ＜必須 / Required＞ •Ph.D. in computational biology, bioinformatics, or other biomedical sciences with a minimum of seven years’ experience in applying bioinformatics approaches to drug discovery/development, preferably in a biopharma setting •Strong publication record in peer reviewed journals •Demonstrated experience in cancer genomics and omics data analyses, including experience with developing pipelines for next-generation sequencing data analysis and QC •Strong capability in designing and performing bioinformatics analyses to address translational questions, and to obtain insight on patient segmentation and biomarker selection •Excellent programming skills (including R, Python, SAS) and deep-knowledge for statistical analysis and machine learning •Experience with data visualization using web application such as Shiny/plotly •Experience with highly parallel, clustered, or supercomputing systems. •Complete independence in providing project level bioinformatics support, from planning to execution and reporting. •Strong communication skills and demonstrated ability to influence and lead in a matrix environment.
＜歓迎 / Preferred＞ •Experience in analyzing single cell sequencing data and proteomics data •Experience in maintaining in-house Laboratory Informatics Management System (LIMS) •Administration experience of clustered-computing systems •Experience with human genetics data and RWD
【応募書類 / Application Documents】 和文履歴書・和文職務経歴書・英文レジュメ Both Japanese and English Resumes are needed
【選考プロセス / Selection details】 書類選考 → 1次面接 → 最終面接 ※変更の可能性もございますので、予めご了承下さい。 CV screening → First interview → Final interview *Please be advised that there might be a change in the process.
【勤務地 / Location】 （雇入れ直後） 東京都中央区 アステラス製薬 日本橋事業所 本社 Nihonbashi, Tokyo
（変更の範囲） 会社の定める事業場および自宅
【勤務開始日 / Start Date】 応相談 Will be decided according to the candidate's flexibility
【契約期間 / Contract Duration】 期間の定めなし Not limited to specified period
【試用期間 / Probation Period】 試用期間原則なし No probation period in principle
【給与 / Salary】 ①基本給：当人の経歴・技術・技能等を考慮して決定 ②裁量労働制の場合：裁量労働手当として職務グレードに応じて50,000～100,000円支給 ③フレックスタイム制の場合：月間の所定労働時間を超えて勤務する時間に対して時間外勤務手当を支給 ①Base salary: will be decided by the candidate's experience, skill and capability. ②When Discretionary Work System is applied: Discretionary work allowance will be paid.(50,000～100,000yen, based on the Grade) ③When Flextime System is applied: Overtime allowance will be paid for time worked in excess of prescribed working hours.
【昇給 / Salary Raise】 有り
【賞与 / Bonus】 有り
【諸手当 / Allowance】 裁量労働手当、住宅手当、通勤手当 等 Discretionary work allowance, Housing allowance, Commutation allowance, etc.
【勤務時間 / Working Hours】 8:45～17:45（月～木）、8:45～16:00（金）、企画業務型 裁量労働制 裁量労働制の場合、所定労働時間を働いたものとみなす 8:45～17:45（Mon～Thu）、8:45～16:00（Fri） Discretionary Work System
【休日 / Holidays】 完全週休２日制（土曜・日曜）、祝日、5月1日、夏季、年末年始 Weekends(Sat and Sun), holidays, May 1st, summer vacation, New Year holidays
【休暇 / Vacation Leave】 年次有給休暇、育児休業制度、介護休業制度 等 Annual paid leave, childcare leave system, nursing care leave system, etc.
【福利厚生 / Welfare】 雇用保険、労災保険、厚生年金、健康保険、共済会制度、社宅制度、持株会制度、財形貯蓄制度 等 Employment Insurance, Industrial Accident Compensation Insurance, Welfare Pension Insurance, Health Insurance, Mutual Aid Association System, Company Housing System, Employee Shareholder Association System, Property Accumulation Savings System
【アステラス製薬 採用サイト/ Career web site】 https://re-jp.astellas.com/jp/recruit/newgraduates/ For more information about Astellas, please visit our career web site. "We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law."